How brain circuits affect drug-seeking behavior in people with addiction
The influence of noradrenergic circuitry on prefrontal neuronal ensemble dynamics and cue-induced heroin seeking
This study is looking at how certain brain areas affect cravings for heroin when people see things that remind them of using it, which could help us understand why some people struggle with addiction and how we might better support them in recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-11044167 on NIH RePORTER |
What this research studies
This research investigates how specific brain circuits in the dorsomedial prefrontal cortex (dmPFC) influence drug-seeking behavior, particularly in response to cues associated with heroin use. By examining the activity of different neuronal populations within the dmPFC, the study aims to understand the variability in responses to drug-related cues and how this may lead to relapse in individuals with substance use disorder. The approach includes advanced techniques like chemogenetics to manipulate neuronal activity and observe changes in behavior. This research could provide insights into the mechanisms of addiction and potential therapeutic targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of heroin use disorder who experience cravings triggered by drug-related cues.
Not a fit: Patients who do not have a history of substance use disorder or those who are not currently experiencing cravings may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for individuals struggling with heroin addiction by targeting specific brain mechanisms involved in drug-seeking behavior.
How similar studies have performed: Previous research has shown promising results in understanding the role of brain circuits in addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Otis, James M — Medical University of South Carolina
- Study coordinator: Otis, James M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.