How brain chemicals affect our perception of sensory information
Noradrenergic modulation of sensory perception
This study is looking at how a part of the brain that helps manage attention affects how we notice things around us, using mice to see how different brain signals can change our focus and decisions about what we sense.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-10610812 on NIH RePORTER |
What this research studies
This research investigates how the brain's norepinephrine system, particularly from a region called the locus coeruleus, influences our ability to perceive sensory stimuli. By studying mice, the researchers will explore how different patterns of norepinephrine activity affect attention and decision-making related to sensory information. The approach involves advanced techniques like multi-channel recordings and optogenetic manipulation to observe and alter brain activity in real-time. This could help us understand why we sometimes miss or notice the same stimuli based on our mental state.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive disorders, anxiety, or attention-related issues.
Not a fit: Patients with stable cognitive function and no sensory processing issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving attention and perception in individuals with cognitive disorders.
How similar studies have performed: Previous research has shown that neuromodulators like norepinephrine play significant roles in cognitive processes, suggesting potential for success in this innovative approach.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Yang, Hongdian — University of California Riverside
- Study coordinator: Yang, Hongdian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.