How brain cells use G proteins to communicate
Alternative Mechanisms of Signaling via Trimeric G Proteins
This work looks at how a recently discovered protein called GINIP changes G protein signaling in brain cells to better understand memory loss in aging and Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11367120 on NIH RePORTER |
What this research studies
This project focuses on a protein called GINIP that helps fine-tune inhibitory signaling between neurons in the brain. Scientists will use molecular, structural, and in vivo experiments in cells and animal models to show how GINIP changes G protein signaling. They will connect those molecular effects to processes involved in cognitive decline and Alzheimer's-related changes. The findings could point to new targets for therapies that adjust brain signaling to protect memory and thinking.
Who could benefit from this research
Good fit: People with mild cognitive impairment, early-stage Alzheimer's disease, or older adults concerned about memory decline may be eligible to provide samples or take part in related translational activities.
Not a fit: Those seeking an immediate clinical treatment or people without memory concerns are unlikely to receive direct benefits from this basic science project.
Why it matters
Potential benefit: Could reveal new molecular targets that lead to treatments to slow or prevent cognitive decline in aging and Alzheimer's disease.
How similar studies have performed: Researchers previously discovered and characterized GINIP at the molecular level, but translating this mechanism into therapies for Alzheimer's is new and largely untested.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Garcia-Marcos, Mikel — Boston University Medical Campus
- Study coordinator: Garcia-Marcos, Mikel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.