How Brain Cells Talk to Each Other to Form Myelin
Neuron-Oligodendrocyte Communication Underlying Myelin Distribution in the Neocortex
This project explores how different types of brain cells communicate to build the protective myelin sheath around nerve fibers in the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11092826 on NIH RePORTER |
What this research studies
Our brains rely on a protective covering called myelin, which helps nerve signals travel quickly and efficiently. This project aims to understand why some parts of the brain have more myelin than others and how nerve cells and myelin-producing cells interact to create these patterns. We want to discover the specific signals and cues that guide myelin formation, which is key to understanding how the brain develops and functions. By mapping these cellular interactions, we hope to uncover fundamental processes that could be important for brain health.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future studies building on this work may seek individuals with neurological conditions affecting myelin.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: Understanding how myelin is formed and distributed could lead to new ways to address conditions where myelin is damaged or not properly formed, such as multiple sclerosis or other neurological disorders.
How similar studies have performed: While the specific mechanisms of neuron-oligodendrocyte communication are still being uncovered, other basic science efforts have successfully advanced our understanding of brain development and disease.
Where this research is happening
Cambridge, United States
- Harvard University — Cambridge, United States (Active)
Researchers
- Principal investigator: Arlotta, Paola — Harvard University
- Study coordinator: Arlotta, Paola
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.