How brain cells respond to radiation and affect sleep and cognition
Official title: Circadian regulation of astrocytic adenosine kinase in the irradiated and cancer brain
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10947288 · Data updated 2026-11-12
This study is looking at how cranial radiotherapy affects brain cells in kids with certain brain tumors, specifically how it might lead to problems with thinking and sleep, and it hopes to find ways to help improve these issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 11, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $406,217 |
| NIH project number | 1R21CA292148-01 |
| Project ID | NIH-10947288 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include pediatric and adult patients who have undergone cranial radiotherapy for brain tumors.
✕Less likely to help
Patients who have not received cranial radiotherapy or those with non-cancerous conditions may not benefit from this research.
What this research studies
This research investigates how cranial radiotherapy (CRT) impacts brain cells called astrocytes and their role in regulating a protective molecule known as adenosine. The study focuses on understanding the mechanisms behind cognitive decline and sleep disruptions that often occur in patients, particularly children and those with certain types of brain tumors, after receiving CRT. By examining the circadian regulation of adenosine kinase in the brain, the research aims to uncover potential therapeutic targets to improve cognitive function and sleep quality in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help improve cognitive function and sleep quality in brain cancer survivors after radiation therapy.
How similar studies have gone: Previous research has shown promising results in understanding the role of circadian rhythms in cancer treatment outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Mahan, Kristin Eckel — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Mahan, Kristin Eckel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.