How brain cells respond to neuron activity in the sense of smell
Astrocyte transcriptional responses to neuronal activity in the olfactory bulb
This study is looking at how certain brain cells called astrocytes react when nerve cells in the part of the brain that helps us smell are activated, especially as we age, to better understand how our brains process smells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11217769 on NIH RePORTER |
What this research studies
This research investigates how astrocytes, a type of brain cell, respond to the activity of neurons in the olfactory bulb, which is responsible for processing smells. By using advanced techniques like in vivo chemogenetic models, the study aims to understand the gene expression changes in astrocytes that occur when neurons are activated by sensory stimuli, such as odors. The researchers will explore the role of a specific transporter, Slc22a3, in astrocyte function and its impact on communication between astrocytes and neurons. This could provide insights into how sensory processing is modulated in the brain, particularly in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above, particularly those experiencing cognitive changes or dementia.
Not a fit: Patients under the age of 65 or those without cognitive impairments may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of sensory processing in the brain, potentially leading to new treatments for age-related cognitive decline and conditions like Alzheimer's disease.
How similar studies have performed: While the specific approach of examining astrocyte responses to neuronal activity in the olfactory bulb is relatively novel, similar studies have shown promising results in understanding brain cell interactions.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Sardar, Debosmita — University of Colorado Denver
- Study coordinator: Sardar, Debosmita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.