How brain cells protect against Alzheimer's disease
Mechanisms of axonal protection by astrocytes and microglia inAlzheimer disease
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10993210
This study is looking at how certain brain cells, called microglia and astrocytes, can help protect against Alzheimer's disease by interacting with harmful substances in the brain, and it aims to find ways to boost their protective abilities to slow down or prevent the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10993210 on ClinicalTrials.gov |
What this research studies
This research investigates the roles of microglia and astrocytes, two types of brain cells, in protecting against Alzheimer's disease. The team aims to understand how these cells interact with amyloid beta deposits, which are harmful aggregates associated with the disease. By using advanced imaging techniques and manipulating these cells in living models, the researchers will explore how to enhance the protective functions of these cells to potentially slow down or prevent neurodegeneration. The findings could lead to new therapeutic strategies targeting these cellular interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease, particularly those showing early signs of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those with other forms of dementia unrelated to amyloid beta accumulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect brain cells and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the protective roles of glial cells in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRUTZENDLER, JAIME — YALE UNIVERSITY
- Study coordinator: GRUTZENDLER, JAIME
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome