How brain cells organize during early development
Mechanism and function of interkinetic nuclear migration in mouse embryonic neural stem cells
['FUNDING_R01'] · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · NIH-11127416
This work explores how brain stem cells arrange themselves in developing brains, which helps us understand conditions like autism.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR (nih funded) |
| Locations | 1 site (COLLEGE STATION, UNITED STATES) |
| Trial ID | NIH-11127416 on ClinicalTrials.gov |
What this research studies
We are looking into how special cells in the brain, called neural stem cells, grow and organize themselves during early development. Understanding this process is key to learning more about how developmental conditions, such as autism, might begin. Our focus is on how these cells move and expand the brain tissue, using models to observe these complex steps. By uncovering these basic mechanisms, we hope to gain insights into brain development and related disorders.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but it is relevant to individuals and families affected by developmental disabilities, including autistic disorder.
Not a fit: Patients seeking immediate clinical interventions or direct treatment options would not find direct benefit from this basic science investigation.
Why it matters
Potential benefit: If successful, this work could provide a deeper understanding of how developmental disabilities like autism arise, potentially guiding future strategies for prevention or treatment.
How similar studies have performed: Previous work by the lead researcher and others has suggested initial clues about these cellular movements, but the specific mechanisms being explored in this project are largely new and untested.
Where this research is happening
COLLEGE STATION, UNITED STATES
- TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR — COLLEGE STATION, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XIE, ZHIGANG — TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
- Study coordinator: XIE, ZHIGANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder