How brain cells move and store neurotransmitters like serotonin
Deciphering the Molecular Mechanisms of Neurotransmitter Transport
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11243477
This work aims to explain how nerve cells load and release neurotransmitters such as serotonin to help people with autism, ADHD, depression, anxiety, and addiction.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11243477 on ClinicalTrials.gov |
What this research studies
From my perspective as someone affected by these conditions, the research looks at the tiny transport proteins that pack neurotransmitters into synaptic vesicles and how those proteins work. Scientists will use biochemical and biophysical lab methods, including protein binding and structural approaches, to see how normal signals and drugs (like amphetamines) interact with these transporters. Much of the work is done in the lab with purified proteins, cells, and model systems to reveal detailed molecular steps. The goal is to turn those molecular findings into ideas that could guide safer, more precise treatments down the road.
Who could benefit from this research
Good fit: People with autism, attention-deficit/hyperactivity disorder, depression, anxiety, or stimulant-use disorders could be relevant candidates for future related clinical protocols or sample donations tied to this research.
Not a fit: Those seeking immediate treatment or people without disorders linked to neurotransmitter function are unlikely to get direct, short-term benefit from this basic laboratory project.
Why it matters
Potential benefit: If successful, this could point to new drug targets or safer approaches to modify neurotransmitter systems, benefiting people with autism, ADHD, mood disorders, anxiety, and substance-use problems.
How similar studies have performed: Existing medicines that target neurotransmitter transporters (for example SSRIs and stimulants) work clinically, but detailed molecular study of synaptic vesicle transporters is less developed and this work is relatively novel.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COLEMAN, JONATHAN — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: COLEMAN, JONATHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Attention Deficit Disorder, Autistic Disorder