How brain cells may help convert astrocytes into neurons after a stroke
Official title: Endothelial Regulation of Astrocyte Trans-Differentiation in Stroke
Funded at Massachusetts General Hospital · NIH-10908490 · Data updated 2026-11-12
This study is looking at how certain brain cells help turn support cells into new neurons after a stroke, with the hope of finding new ways to help stroke patients recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 17, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $458,090 |
| NIH project number | 5R01NS132945-02 |
| Project ID | NIH-10908490 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have experienced a stroke or acquired brain injury.
✕Less likely to help
Patients with conditions unrelated to stroke or those who are not within the specified age range may not benefit from this research.
What this research studies
This research investigates the role of brain endothelial cells in promoting the conversion of astrocytes into neurons following a stroke. By examining how these cells secrete factors that support neural stem cells, the study aims to understand the mechanisms behind neurogenesis in stroke recovery. The researchers will utilize various techniques, including mouse genetics and imaging, to explore how these signals can enhance recovery in stroke models. The ultimate goal is to identify new therapeutic strategies that could improve outcomes for stroke patients.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance recovery and neuroregeneration in stroke patients.
How similar studies have gone: Previous research has shown promising results in similar approaches, indicating potential for success in this novel investigation.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Lo, Eng H. — Massachusetts General Hospital
- Study coordinator: Lo, Eng H.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.