How brain cells keep track of time and respond to daily cycles
Micro-Anatomical Mechanisms of Neuronal Circadian Timekeeping, Output, and Entrainment
This study looks at how brain cells keep track of time and adjust to changes in our environment, which could help people understand their sleep patterns and health issues related to disrupted body clocks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-11080295 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which brain cells, specifically those involved in circadian rhythms, maintain an internal sense of time and synchronize with environmental changes. It focuses on understanding the complex neural networks and signaling processes that allow these cells to function effectively. By studying both local and long-distance signaling among neurons, the research aims to uncover how these processes contribute to health challenges associated with disrupted circadian rhythms. Patients may benefit from insights gained into how their biological clocks operate and how they can be influenced by external factors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing sleep disorders or other health issues linked to circadian rhythm disruptions.
Not a fit: Patients with stable circadian rhythms and no related health issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for health issues related to circadian rhythm disruptions, such as sleep disorders and metabolic diseases.
How similar studies have performed: Previous research has shown promising results in understanding circadian rhythms and their impact on health, suggesting that this approach could yield valuable insights.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Shafer, Orie T — Trustees of Indiana University
- Study coordinator: Shafer, Orie T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.