How brain cells influence reactions to alcohol
Official title: Astrocyte modulation of striatal neuronal activity and behavioral sensitivity to alcohol
Funded at Rutgers, the State Univ of N.j. · NIH-11068123 · Data updated 2026-11-12
This study is looking at how certain brain cells called astrocytes influence how other brain cells react to alcohol, which could help us understand alcohol use disorder better and find ways to lessen its effects.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | January 15, 2025 |
| Project end | January 14, 2027 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 1F32AA032173-01 |
| Project ID | NIH-11068123 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who experience varying responses to alcohol, particularly those at risk for alcohol use disorder.
✕Less likely to help
Patients who do not consume alcohol or have no interest in alcohol-related behaviors may not benefit from this research.
What this research studies
This research investigates how astrocytes, a type of brain cell, affect the way neurons in the striatum respond to alcohol. By observing the calcium activity in astrocytes and the activity of neurons, the study aims to understand the balance between stimulant and sedative effects of alcohol. The researchers will use advanced techniques to manipulate astrocyte activity and assess its impact on alcohol-related behaviors. This could provide insights into the mechanisms behind alcohol use disorder and how to potentially mitigate its effects.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating alcohol use disorder.
How similar studies have gone: Previous research has shown that understanding the role of astrocytes in brain function can lead to significant insights, suggesting potential for success in this novel approach.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Ardinger, Cherish — Rutgers, the State Univ of N.j.
- Study coordinator: Ardinger, Cherish
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.