How brain cells help regulate oxygen levels in the brain
Official title: Role of interneurons in brain tissue oxygen regulation
Funded at Endeavor Health Clinical Operations · NIH-11046067 · Data updated 2026-11-12
This study is looking at how certain brain cells help manage oxygen levels in the brain, which is important for keeping our brains healthy, and it aims to understand how these cells work with blood vessels to ensure the brain gets enough oxygen, which could help us learn more about how the brain works normally and in conditions that affect blood flow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endeavor Health Clinical Operations NIH-funded |
| Lab location | 1 site (Evanston, United States) |
| Project start | August 1, 2018 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $410,000 |
| NIH project number | 2R01NS107383-06A1 |
| Project ID | NIH-11046067 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting brain oxygenation or vascular health.
✕Less likely to help
Patients with no neurological or vascular issues may not receive direct benefits from this research.
What this research studies
This research investigates the role of GABAergic interneurons in regulating oxygen levels within brain tissue, which is essential for maintaining healthy brain function. The study aims to understand how these interneurons interact with blood vessels to control blood flow and oxygen delivery. By examining the mechanisms of oxygen regulation through specific experiments, the research seeks to clarify the relationship between neuronal activity and oxygenation in the brain. This could provide insights into both normal brain functioning and conditions that affect blood flow.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of brain conditions related to oxygen regulation and vascular dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding the role of interneurons in brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Endeavor Health Clinical Operations
Evanston, United States Active
Researchers
- Principal investigator: Aksenov, Daniil — Endeavor Health Clinical Operations
- Study coordinator: Aksenov, Daniil
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.