How brain cells help regulate blood flow during low blood sugar
Astrocyte regulation of cerebral blood flow during hypoglycemia
This study is looking at how certain brain cells help control blood flow when blood sugar levels drop, which is something people with diabetes often experience, to find better ways to protect the brain during these low-sugar episodes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10870194 on NIH RePORTER |
What this research studies
This research investigates the role of astrocytes, a type of brain cell, in regulating blood flow in the brain during episodes of low blood sugar, which is a common complication for people with diabetes. By using advanced imaging techniques, the study will monitor changes in calcium signaling within astrocytes and the diameter of blood vessels as blood glucose levels are lowered. The goal is to understand how these cells contribute to increasing blood flow to protect the brain from damage during hypoglycemia. This could lead to new insights into managing diabetes-related complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who experience episodes of hypoglycemia.
Not a fit: Patients who do not have diabetes or do not experience hypoglycemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve understanding of how to prevent brain damage and cognitive deficits in patients experiencing hypoglycemia.
How similar studies have performed: Other research has shown promising results regarding the role of astrocytes in brain function, making this approach both relevant and potentially impactful.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Newman, Eric a — University of Minnesota
- Study coordinator: Newman, Eric a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.