How brain cells create myelin in response to activity
Official title: Mechanisms of activity-dependent myelination through oligodendrocyte exocytosis
Funded at Stanford University · NIH-11098472 · Data updated 2026-11-12
This study is looking at how certain brain cells help create a protective layer around nerve fibers, especially when we learn new things or experience different sensations, which could lead to new treatments for conditions like Alzheimer's and Parkinson's disease.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $101,248 |
| NIH project number | 5K99NS136783-02 |
| Project ID | NIH-11098472 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with neurological conditions such as Alzheimer's disease or those experiencing cognitive decline.
✕Less likely to help
Patients with neurological disorders unrelated to myelin loss or those who do not have cognitive impairments may not benefit from this research.
What this research studies
This research investigates the mechanisms by which brain cells called oligodendrocytes produce myelin, a protective sheath that insulates nerve fibers, particularly in response to neuronal activity. The study focuses on understanding how myelin formation can be stimulated through learning and sensory experiences, which may have implications for treating neurological disorders like Alzheimer's and Parkinson's disease. By exploring the cellular processes involved in myelin production, the research aims to uncover new strategies for enhancing brain health and function. Patients may benefit from insights that could lead to innovative therapies for conditions associated with myelin loss.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance myelin repair and improve cognitive function in patients with neurological disorders.
How similar studies have gone: Previous research has shown promising results in understanding myelin formation and its role in neuroplasticity, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Lam, Mable — Stanford University
- Study coordinator: Lam, Mable
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.