How brain cells control blood flow in health and Alzheimer's disease
Pericytes as metabolic sentinels in the control of brain blood flow in health and Alzheimer's disease
This study is looking at special cells in the brain that help control blood flow, which is really important for brain health, especially in people with Alzheimer's disease, to find new ways to support their brain function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10877168 on NIH RePORTER |
What this research studies
This research investigates the role of pericytes, specialized cells that support blood vessels in the brain, in regulating blood flow essential for neuron function. By understanding how these cells respond to changes in energy supply, particularly in the context of Alzheimer's disease, the research aims to uncover mechanisms that may be disrupted in this condition. The study employs advanced techniques to isolate and analyze pericytes, focusing on their ability to control blood vessel contraction and relaxation. Insights gained could lead to new therapeutic targets for improving brain health in Alzheimer's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia not related to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood flow in the brains of Alzheimer's patients, potentially slowing disease progression.
How similar studies have performed: Previous research has shown that understanding blood flow regulation in the brain can lead to significant advancements in treating neurodegenerative diseases, suggesting this approach has potential for success.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Longden, Thomas a — University of Maryland Baltimore
- Study coordinator: Longden, Thomas a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.