How brain cells connect during development
Mechanistic studies of molecular recognition and signaling of neuronal wiring receptors
Researchers are uncovering how neurons use specific surface proteins to make the right connections during development to help people with autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11326672 on NIH RePORTER |
What this research studies
This project uses biochemical tests and genetic experiments to find which cell-surface proteins help neurons recognize and connect to the right partners. Scientists study interaction networks discovered in model organisms (like fruit flies) and map the signaling steps those proteins trigger. By changing these proteins in lab models, they watch how wiring and behavior are altered. The goal is to build a detailed map of the molecules and pathways that guide circuit assembly relevant to neurodevelopmental conditions such as autism.
Who could benefit from this research
Good fit: People with autism or their caregivers who are interested in contributing samples or participating in future translational or follow-up studies would be most relevant.
Not a fit: Individuals seeking immediate clinical treatments or those without neurodevelopmental conditions are unlikely to receive direct clinical benefit from this basic laboratory research.
Why it matters
Potential benefit: If successful, the work could reveal molecular targets and pathways that guide future diagnostics or therapies for autism by explaining how neural wiring can go wrong.
How similar studies have performed: Related lab studies have identified similar protein families that shape neural wiring in animal models, but translating those findings into human treatments is still early and largely untested.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Ozkan, Engin — University of Chicago
- Study coordinator: Ozkan, Engin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.