How Brain Cells Communicate
Presynaptic regulation of neurotransmitter release in mammalian neuronal circuits
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11191824
This project explores how brain cells send messages to each other, which is important for understanding conditions like migraine, epilepsy, and ataxia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11191824 on ClinicalTrials.gov |
What this research studies
Our brains rely on tiny electrical signals to send messages between cells, a process called neurotransmitter release. This project focuses on a specific channel, CaV2.1, which plays a key role in making sure these messages are sent efficiently and precisely. We want to understand the exact steps involved in how these channels work at the connections between brain cells. By learning more about this fundamental process, we hope to uncover why it sometimes goes wrong in certain brain conditions.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future studies building on this knowledge may seek individuals with neurological conditions related to CaV2.1 channel function.
Not a fit: Patients seeking immediate clinical interventions or direct treatment options would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide a deeper understanding of the basic mechanisms underlying neurological disorders like migraine, epilepsy, and ataxia, potentially leading to new treatment approaches.
How similar studies have performed: This research builds upon existing knowledge of neurotransmitter release and calcium channels, aiming to uncover novel molecular mechanisms that are not yet fully understood.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YOUNG, SAMUEL MATTHEW — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: YOUNG, SAMUEL MATTHEW
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.