How brain cells change during learning
Compartment-Specific Synaptic Organization and Plasticity During Learning
['FUNDING_CAREER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11112253
This study is looking at how tiny parts of brain cells called dendrites change and connect while animals learn new things, helping us understand more about how our brains work when we remember and learn.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11112253 on ClinicalTrials.gov |
What this research studies
This research investigates how different parts of brain cells, specifically dendrites, organize and change their connections during the learning process. By using advanced imaging techniques, the study aims to observe how synaptic inputs are arranged in these dendrites in live animals as they learn. The researchers will explore the unique properties of these compartments and how they influence the brain's ability to process information. This work could provide insights into the fundamental mechanisms of learning and memory.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative conditions such as Alzheimer's disease or those affected by addiction.
Not a fit: Patients with acute neurological injuries or those not experiencing cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of learning processes and potentially lead to new treatments for conditions like Alzheimer's disease and addiction.
How similar studies have performed: Previous research has shown promising results in understanding synaptic organization and plasticity, suggesting that this approach could yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WRIGHT, WILLIAM JAMES — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: WRIGHT, WILLIAM JAMES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder, Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease