How brain cells called glia control protein making
Regulation of local translation in glia
This project explores how brain cells called astrocytes make proteins in specific locations, which is important for brain function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11118903 on NIH RePORTER |
What this research studies
Our brains rely on specialized cells called astrocytes, which are a type of glia, to function properly. This project aims to understand how these astrocytes precisely control where and when they create new proteins, a process called local translation. We believe that specific parts of the genetic code within these proteins act like instructions, guiding them to the right places in the astrocyte. To uncover these instructions, we are developing new, advanced methods to study how astrocytes regulate protein production both normally and when they receive signals. This basic understanding is crucial because astrocytes play a vital role in brain health and disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future applications could benefit individuals with neurological conditions linked to astrocyte dysfunction.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: Understanding how astrocytes regulate protein production could lead to new ways to address brain disorders related to learning, memory, and other neurological functions.
How similar studies have performed: While local translation has been studied in neurons, its regulation in astrocytes is a newer area of investigation, with prior work from this team providing initial evidence.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Dougherty, Joseph D — Washington University
- Study coordinator: Dougherty, Joseph D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.