How brain cells called astrocytes control brain changes in response to stress
Control of extracellular matrix remodeling by CD29+ astrocytes
This work explores how specialized brain cells called astrocytes help the brain adapt to stress by changing its support structure, which could help us understand stress-related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11134441 on NIH RePORTER |
What this research studies
Our brains have a complex support network called the extracellular matrix (ECM) that helps brain cells communicate and function. When we experience unpredictable stress, this network can change, influencing how our brain responds and our behavior. This project looks at how astrocytes, a type of brain cell, use specific proteins called integrins to control these ECM changes in a key brain area involved in reward and stress. Understanding these processes could reveal new ways to support brain health when facing stress.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals experiencing stress-related conditions, as it aims to understand the basic brain mechanisms involved in stress adaptation.
Not a fit: Patients seeking immediate clinical interventions or direct treatment options would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could uncover fundamental mechanisms of how the brain copes with stress, potentially leading to new strategies for treating stress-related mental health conditions.
How similar studies have performed: Previous research has identified key markers in astrocytes in response to inflammation, providing a foundation for this novel investigation into their role in stress-induced ECM remodeling.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Wheeler, Michael Alex — Brigham and Women's Hospital
- Study coordinator: Wheeler, Michael Alex
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.