How brain cells affect breathing changes after low oxygen exposure
Microglial regulation of intermittent hypoxia induced phrenic motor plasticity
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-10545056
This study is looking at how certain brain cells help our breathing adapt when we experience low oxygen levels, which could help improve breathing for people with respiratory issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10545056 on ClinicalTrials.gov |
What this research studies
This research investigates how microglial cells, which are immune cells in the brain, influence the ability of the respiratory system to adapt to changes in oxygen levels. The study focuses on understanding the mechanisms behind a specific type of respiratory plasticity called phrenic long-term facilitation (pLTF), which occurs after episodes of intermittent hypoxia. By using animal models, the researchers will explore how different levels of hypoxia affect the signaling pathways involved in breathing regulation, particularly in the context of inflammation. This could lead to insights into how breathing can be improved in patients with respiratory disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with respiratory disorders or conditions that affect breathing.
Not a fit: Patients without any respiratory issues or those who are not affected by hypoxia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance breathing function in patients with respiratory conditions.
How similar studies have performed: While the role of microglia in other neural systems has been studied, this specific investigation into their role in respiratory plasticity is relatively novel.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MITCHELL, GORDON S. — UNIVERSITY OF FLORIDA
- Study coordinator: MITCHELL, GORDON S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.