How brain cells affect blood flow in Alzheimer's disease and stroke.
Official title: Astrocyte regulation of cerebral blood flow at the intersection of ischemia and Alzheimer's disease
Funded at Oregon Health & Science University · NIH-10933579 · Data updated 2026-11-12
This study is looking at how certain brain cells called astrocytes help control blood flow in the brain, especially in people with Alzheimer's disease or after a stroke, to find out how they might affect thinking and memory, with the hope of discovering new ways to support brain health for those who need it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $672,643 |
| NIH project number | 5R01NS134592-02 |
| Project ID | NIH-10933579 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals aged 65 and older who are experiencing symptoms of Alzheimer's disease or have a history of ischemic injuries.
✕Less likely to help
Patients who are younger than 65 or do not have Alzheimer's disease or related cognitive impairments may not benefit from this research.
What this research studies
This research investigates the role of astrocytes, a type of brain cell, in regulating blood flow in the brain, particularly in the context of Alzheimer's disease and ischemic injuries. The study aims to understand how these cells influence cerebrovascular reactivity and neurovascular coupling, which are crucial for maintaining healthy brain function. By examining the effects of ischemic injuries on astrocyte behavior and blood flow regulation, the research seeks to uncover the underlying mechanisms that contribute to cognitive decline in dementia patients. The findings could lead to new therapeutic strategies for improving brain health in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to novel interventions that improve blood flow regulation in the brains of Alzheimer's patients, potentially slowing cognitive decline.
How similar studies have gone: Previous studies have shown promising results in understanding the relationship between astrocytes and blood flow regulation in neurological disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Mishra, Anusha — Oregon Health & Science University
- Study coordinator: Mishra, Anusha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.