How brain cells affect blood flow in Alzheimer's disease and stroke.
Astrocyte regulation of cerebral blood flow at the intersection of ischemia and Alzheimer's disease
This study is looking at how certain brain cells called astrocytes help control blood flow in the brain, especially in people with Alzheimer's disease or after a stroke, to find out how they might affect thinking and memory, with the hope of discovering new ways to support brain health for those who need it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10933579 on NIH RePORTER |
What this research studies
This research investigates the role of astrocytes, a type of brain cell, in regulating blood flow in the brain, particularly in the context of Alzheimer's disease and ischemic injuries. The study aims to understand how these cells influence cerebrovascular reactivity and neurovascular coupling, which are crucial for maintaining healthy brain function. By examining the effects of ischemic injuries on astrocyte behavior and blood flow regulation, the research seeks to uncover the underlying mechanisms that contribute to cognitive decline in dementia patients. The findings could lead to new therapeutic strategies for improving brain health in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 65 and older who are experiencing symptoms of Alzheimer's disease or have a history of ischemic injuries.
Not a fit: Patients who are younger than 65 or do not have Alzheimer's disease or related cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel interventions that improve blood flow regulation in the brains of Alzheimer's patients, potentially slowing cognitive decline.
How similar studies have performed: Previous studies have shown promising results in understanding the relationship between astrocytes and blood flow regulation in neurological disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Mishra, Anusha — Oregon Health & Science University
- Study coordinator: Mishra, Anusha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.