How brain cell interactions affect HIV latency
Regulation of HIV latency by microglial-neuronal interactions
This study is looking at how brain cells talk to each other and how that affects the HIV virus hiding in the brain, especially for people who use drugs like methamphetamine, to help find better ways to manage HIV for those who might also have memory or thinking problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10674037 on NIH RePORTER |
What this research studies
This research investigates how interactions between brain cells, specifically microglia and neurons, influence the latency of HIV in the brain. It focuses on understanding the communication signals that can either silence or reactivate the virus, particularly in the context of substance use, such as methamphetamine, which is common among HIV-positive individuals. By using advanced models of human brain cells, the study aims to uncover the mechanisms behind HIV reactivation and the impact of neurocognitive disorders like HAND. The findings could lead to new strategies for managing HIV in patients with substance use issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV-positive individuals who also engage in substance use and may be at risk for neurocognitive disorders.
Not a fit: Patients who are HIV-negative or do not have a history of substance use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for HIV-positive individuals, particularly those who also struggle with substance use, by preventing HIV reactivation in the brain.
How similar studies have performed: Previous research has shown promising results in understanding the interactions between microglia and neurons in the context of HIV, suggesting that this approach has potential for success.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Karn, Jonathan — Case Western Reserve University
- Study coordinator: Karn, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.