How brain cell activity affects glucose use and neuron growth in the hippocampus
Activity-dependent astrocyte glucose dynamics regulate hippocampal neurogenesis
This study looks at how brain cell activity affects the way supportive brain cells use sugar, and how this process might help new brain cells survive, especially as we age or in the case of Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-11050839 on NIH RePORTER |
What this research studies
This research investigates how the activity of neurons in the hippocampus influences the metabolism of glucose by astrocytes, which are supportive brain cells. It focuses on understanding how this glucose metabolism impacts the survival of newly formed neurons, particularly in the context of aging and Alzheimer's disease. The study employs advanced techniques to explore the relationship between neuronal activity and astrocyte function, aiming to uncover mechanisms that could enhance neurogenesis in healthy and diseased brains.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older, particularly those experiencing age-related cognitive decline or Alzheimer's disease.
Not a fit: Patients who are younger than 21 or do not have any cognitive decline or neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting brain health and neurogenesis, particularly in aging populations and those affected by Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of astrocytes and glucose metabolism in neurogenesis, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Ge, Shaoyu — State University New York Stony Brook
- Study coordinator: Ge, Shaoyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.