How brain capillaries sense neuronal activity to regulate blood flow
Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and Disease
This study looks at how tiny blood vessels in the brain react when brain cells are active, helping to ensure that the brain gets enough blood when it needs it, and it aims to find out how this process might be linked to brain disorders where blood flow isn't working properly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-11001968 on NIH RePORTER |
What this research studies
This research investigates how brain capillaries respond to neuronal activity to control blood flow in the brain. It focuses on the mechanisms of neurovascular coupling, which is the process by which active neurons signal nearby blood vessels to increase blood supply. The study explores the role of specific ion channels and signaling pathways in this process, aiming to uncover how these interactions support brain function and health. By understanding these mechanisms, the research seeks to provide insights into brain disorders where blood flow regulation is impaired.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that affect blood flow in the brain, such as stroke or neurodegenerative diseases.
Not a fit: Patients with stable neurological conditions that do not involve issues with cerebral blood flow may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for brain disorders by improving our understanding of how to regulate blood flow in the brain.
How similar studies have performed: Other research has shown promising results in understanding neurovascular coupling, indicating that this approach has potential for significant advancements in the field.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Nelson, Mark T — University of Vermont & St Agric College
- Study coordinator: Nelson, Mark T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.