How brain activity supports memory and behavior
Hippocampal network mechanisms for memory-guided behavior
This study is looking at how certain brain waves in a part of the brain called the hippocampus help us remember things and guide our actions, which could help us understand how memories work better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10659127 on NIH RePORTER |
What this research studies
This research investigates the mechanisms in the hippocampus that underlie memory-guided behavior, focusing on how brain oscillations reflect coordinated neuronal activity. By examining the dentate-CA3 network, the study aims to understand how information is retained and organized during complex memory tasks. The researchers will analyze high-frequency oscillations known as sharp-wave ripples, which are believed to play a crucial role in replaying behaviorally relevant events. This work could provide insights into the dynamic nature of memory processing and its relationship with behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing memory impairments, particularly those related to aging or Alzheimer's disease.
Not a fit: Patients with memory issues not related to the hippocampal function or those with other neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for memory-related disorders such as Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding brain oscillations and memory, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Leutgeb, Jill K — University of California, San Diego
- Study coordinator: Leutgeb, Jill K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.