How brain activity affects gene regulation and memory formation
Chromatin regulation of neuronal activity-induced enhancer priming and epigenetic memory
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11072249
This study is looking at how brain activity affects the way our genes work, especially in relation to behaviors like addiction, to help find new ways to treat brain disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11072249 on ClinicalTrials.gov |
What this research studies
This research investigates how neuronal activity influences gene expression and the resulting long-term changes in brain function. It focuses on the role of chromatin regulators and signaling pathways in priming genes for faster responses to future stimuli, which may contribute to behavioral adaptations. The study aims to understand the mechanisms behind epigenetic memory, particularly in relation to conditions like addiction. By examining the interactions between chromatin remodeling complexes and activity-regulated genes, the research seeks to uncover insights that could lead to new therapeutic strategies for brain disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental or psychiatric disorders, particularly those affected by conditions related to synaptic plasticity and memory.
Not a fit: Patients with acute brain injuries or those not experiencing any neurological or psychiatric conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for brain disorders by enhancing our understanding of how memories and behaviors are formed at the molecular level.
How similar studies have performed: Previous research has shown promising results in understanding the role of chromatin regulation in neuronal activity, suggesting that this approach could yield valuable insights.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WU, JIANG — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: WU, JIANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.