How Bordetella pertussis interacts with human nasal cells
Interaction of Bordetella pertussis with human nasal epithelium
This study is looking at how the whooping cough germ sticks around in the noses of people, even those who have been vaccinated and might not show many symptoms, to help find ways to make vaccines better and understand how the disease spreads.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11093534 on NIH RePORTER |
What this research studies
This research investigates how the bacterium Bordetella pertussis, which causes whooping cough, interacts with human nasal epithelial cells. The study aims to understand the mechanisms by which this bacterium attaches to and persists in the nasal cavity, particularly in vaccinated individuals who may show mild or no symptoms. By using human nasal epithelial cultures that mimic the natural environment of the human nose, researchers will explore how biofilm formation contributes to long-term infection. This approach could provide insights into improving vaccine effectiveness and understanding disease transmission.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and young children, especially those under 11 years old who may be at risk for whooping cough.
Not a fit: Patients who are older than 11 years or those who have already been diagnosed with chronic respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and strategies to prevent whooping cough, particularly in young children.
How similar studies have performed: Previous research has shown that understanding bacterial interactions in human tissues can lead to significant advancements in vaccine development, indicating potential success for this approach.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Deora, Rajendar K — Ohio State University
- Study coordinator: Deora, Rajendar K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.