How bone stem cells work in osteogenesis imperfecta (brittle bone disease)
Regulation of Skeletal progenitor cells in Osteogenesis Imperfecta
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11313819
This project looks at how the abnormal bone environment in osteogenesis imperfecta affects the stem cells that help bones grow and heal, aiming to improve repair for people with OI.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11313819 on ClinicalTrials.gov |
What this research studies
As someone with OI, this research follows the periosteal stem/progenitor cells that help bones regenerate to see how they are changed by the defective collagen matrix. Researchers will use lab animal models alongside samples of human periosteal cells and label cells with genetic markers (Mx1 and αSMAGFP) to track long-term stem cell behavior. They will focus on a receptor called KDR (VEGFR2) that these periosteal cells express and test how these cells contribute to bone repair. The goal is to understand why healing is altered in OI and to provide knowledge that could guide future treatments to improve bone regeneration.
Who could benefit from this research
Good fit: Ideal candidates would be people with osteogenesis imperfecta who are willing to provide tissue samples or take part in related clinical/observational work at participating sites.
Not a fit: People without OI or those expecting an immediate new treatment are unlikely to benefit directly, since this is a basic/translational research project rather than a treatment trial.
Why it matters
Potential benefit: If successful, this work could point to ways to boost bone healing and reduce fractures or craniofacial defects for people with OI.
How similar studies have performed: Previous research has identified periosteal skeletal stem cells and some markers like KDR, but applying these findings specifically to OI and its abnormal extracellular matrix is a newer, translational effort.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARK, DONGSU — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: PARK, DONGSU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bone Diseases, Bone Injury, Brittle bone disorder