How bone morphogenetic proteins affect stomach cell changes linked to cancer
Regulation of gastric metaplasia, dysplasia and neoplasia by Bone Morphogenetic Protein signaling
This study is looking at how long-term inflammation in the stomach might change stomach cells in a way that could lead to cancer, and it’s exploring how certain proteins can help control this process, which could be helpful for people dealing with stomach issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10649637 on NIH RePORTER |
What this research studies
This research investigates how chronic inflammation in the stomach can lead to abnormal changes in gastric epithelial cells, potentially resulting in cancer. It focuses on the role of bone morphogenetic proteins (BMPs) in regulating these changes and inhibiting inflammation and cell growth. By studying specific cell types in transgenic mice, the research aims to uncover the mechanisms behind the development of gastric neoplasms and how BMP signaling influences these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic gastric inflammation or those at risk for gastric neoplasms.
Not a fit: Patients without chronic gastric inflammation or those who do not have a history of gastric neoplasms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating gastric cancer by targeting BMP signaling pathways.
How similar studies have performed: Previous research has shown promising results in understanding the role of BMPs in gastrointestinal health, suggesting that this approach may yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Todisco, Andrea — University of Michigan at Ann Arbor
- Study coordinator: Todisco, Andrea
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.