How bone marrow inflammation changes immunity in acute myeloid leukemia
The role of inflammation in the regulation of immune response in acute myeloid leukemia
This project will find out whether lowering bone marrow inflammation helps adults with acute myeloid leukemia respond better to treatment and live longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11115785 on NIH RePORTER |
What this research studies
We will use data and samples from a large group of about 1,600 adults with AML to compare people who have high versus low inflammation in their bone marrow. Researchers will track inflammatory changes over time during standard treatments and look at how those changes relate to treatment response and survival. Lab studies that prompted this work showed inflammation can speed leukemia in animals, and the team will test drugs that block key inflammatory signals as a possible way to improve outcomes. The goal is to link patient samples, clinical outcomes, and targeted anti-inflammatory approaches to find ways to help people with AML.
Who could benefit from this research
Good fit: Adults with acute myeloid leukemia (age 21 and older), especially those with signs of high bone marrow inflammation or certain cooperating mutations, would be the main candidates.
Not a fit: People without AML, children, or patients whose disease shows low bone marrow inflammation are unlikely to be helped directly by this project.
Why it matters
Potential benefit: If successful, this work could lead to treatments that reduce harmful inflammation and improve treatment response and survival for people with AML.
How similar studies have performed: Animal studies have shown that inflammation can drive AML progression, but clinical efforts directly targeting inflammation in AML patients are still limited and early.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Aifantis, Iannis — New York University School of Medicine
- Study coordinator: Aifantis, Iannis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.