How bone marrow cells help clear dead cells and affect aging bones
Efferocytosis by Bone Marrow Stromal Cells and Bone Aging
['FUNDING_R01'] · UNIVERSITY OF ROCHESTER · NIH-11032003
This study is looking at how special stem cells from bone marrow help clean up dead cells and how this affects bone health as we get older, with the goal of finding ways to keep our bones strong and healthy in later life.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11032003 on ClinicalTrials.gov |
What this research studies
This research investigates the role of bone marrow-derived stem cells in clearing dead cells and how this process affects bone health as we age. The study focuses on understanding how these cells, known as mesenchymal stromal cells (MSCs), contribute to age-related bone loss and dysfunction. By examining the mechanisms of efferocytosis, where MSCs engulf and digest apoptotic cells, the research aims to uncover potential therapeutic strategies to improve bone maintenance and health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing age-related bone health issues.
Not a fit: Patients with acute bone injuries or conditions unrelated to aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance bone health and prevent age-related bone loss.
How similar studies have performed: While some preliminary studies have shown promise in understanding MSC functions, this specific approach to efferocytosis and its impact on bone aging is relatively novel.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CALVI, LAURA M — UNIVERSITY OF ROCHESTER
- Study coordinator: CALVI, LAURA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.