How body signals guide stem cells for tissue health
Regulation of tissue stem cell lineages by nuclear receptor signaling
This project explores how signals from different parts of the body, like hormones, help guide stem cells to maintain and repair our tissues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-11113808 on NIH RePORTER |
What this research studies
Our bodies rely on stem cells to keep tissues healthy and fix them when they're damaged throughout our lives. This project looks at how changes in our body's overall health, such as shifts in fat cell activity or hormone levels, can affect these important stem cells. We are focusing on special proteins called nuclear receptors, which act like messengers for these body signals. Understanding how these messengers work could help us learn more about how our tissues stay healthy and what goes wrong in certain conditions.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to understand basic biological processes relevant to adults with conditions affecting tissue maintenance, metabolism, or hormone regulation.
Not a fit: Patients seeking immediate new treatments or clinical trial opportunities would not directly benefit from this basic science project.
Why it matters
Potential benefit: This work could lead to a better understanding of how our bodies maintain and repair tissues, potentially informing future treatments for conditions related to stem cell dysfunction or metabolic imbalances.
How similar studies have performed: This project builds upon existing knowledge of nuclear receptors and stem cell biology, exploring novel aspects of inter-organ communication.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Weaver, Lesley Nicole — Trustees of Indiana University
- Study coordinator: Weaver, Lesley Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.