How body fat affects the heart's metabolism during cardiac stress
Adipose tissue mediates cardiac metabolic remodeling in the pathologically stressed heart in the absence of primary metabolic stress
This research looks at how fat tissue signals change the heart's metabolism when the heart is under stress, with the goal of helping people who develop heart failure or cardiac hypertrophy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11296901 on NIH RePORTER |
What this research studies
This project studies how your body fat (both white and brown fat) changes when the heart faces pathological stress like pressure overload. The researchers will track heart and fat-tissue signals, measure hormones such as natriuretic peptides and how the heart uses long-chain fatty acids, and look for differences between males and females. They will examine how fat tissue changes (for example, beiging of white fat or increased fat breakdown) influence the heart's lipid profile and metabolic remodeling. The work combines molecular and tissue-level measurements from experimental models to identify ways fat could protect or harm the stressed heart.
Who could benefit from this research
Good fit: People with or at risk for heart failure, cardiac hypertrophy, or pressure-overload conditions (for example due to aortic stenosis) would be the most relevant group for related future clinical studies.
Not a fit: Individuals whose heart disease is driven primarily by metabolic conditions like obesity or uncontrolled diabetes may not directly benefit from findings focused on heart-driven adipose responses.
Why it matters
Potential benefit: If successful, this could identify new fat-related targets to prevent or reduce harmful metabolic changes in the heart during heart failure or pressure overload.
How similar studies have performed: Past studies have linked fat-derived signals to heart metabolism, but exploring adipose plasticity and sex-specific responses during pressure-overload heart stress is relatively new and less tested.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Lewandowski, E Douglas — Ohio State University
- Study coordinator: Lewandowski, E Douglas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.