How body clocks affect obesity and metabolism
Cross-regulation of Immunometabolism and Circadian Pathways in Obesity Pathophysiology
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-11059137
This study is looking at how our body clocks affect weight gain and health, especially when we eat high-fat foods at the wrong times, and it hopes to find out if eating in sync with our natural rhythms can help improve how our bodies handle sugar and fat.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11059137 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between circadian rhythms and obesity, focusing on how disruptions in our internal body clocks can lead to metabolic issues. It examines how high-fat diets misalign these rhythms and affect gene expression in fat tissue, which plays a crucial role in energy balance and glucose regulation. The study aims to understand how aligning meal times with our natural circadian cycles can improve insulin sensitivity and overall health. By analyzing metabolic processes in fat cells, the research seeks to uncover new insights into obesity management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with obesity, particularly those who experience irregular sleep patterns or work shifts that disrupt their circadian rhythms.
Not a fit: Patients who do not have issues related to obesity or metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating obesity and related metabolic disorders.
How similar studies have performed: Previous research has shown promising results in understanding the impact of circadian rhythms on metabolism, suggesting that this approach could yield significant insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BASS, JOSEPH — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: BASS, JOSEPH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.