How blood vessels help cancer cells grow by transporting fatty acids
Official title: Vascular regulation of fatty acid transport in metastatic tumor outgrowth
Funded at Vanderbilt University Medical Center · NIH-10895442 · Data updated 2026-11-12
This study is looking at how blood vessels help cancer cells get the fatty acids they need to grow and spread, and it aims to understand how changes in these blood vessels might affect cancer development, so it's for anyone interested in how cancer works and how we might improve treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $480,397 |
| NIH project number | 5R01CA271176-02 |
| Project ID | NIH-10895442 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with metastatic cancer who may benefit from therapies aimed at disrupting fatty acid transport.
✕Less likely to help
Patients with localized tumors that have not metastasized may not receive direct benefits from this research.
What this research studies
This research investigates the role of blood vessels in supplying fatty acids to cancer cells, which is crucial for their growth and spread. It focuses on understanding how vascular endothelial cells regulate the transport and utilization of fatty acids in metastatic tumors. By examining the mechanisms involved, the study aims to uncover how changes in blood vessel function can influence tumor development and progression. The research employs advanced techniques to analyze fatty acid transport and metabolism in the context of cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating metastatic cancer by targeting fatty acid transport mechanisms.
How similar studies have gone: Other research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach could also be effective.
Where this research is happening
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Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Chen, Jin — Vanderbilt University Medical Center
- Study coordinator: Chen, Jin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.