How blood vessel interactions affect brain development in children with heart defects
Oligo-Vascular Crosstalk in the Developing Brain: Implications for White Matter Injury in Congenital Heart Disease
This study is looking at how blood vessels and brain development are connected in young children with congenital heart disease, to better understand how these connections might cause brain injuries, especially in the white matter, and help improve recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11035708 on NIH RePORTER |
What this research studies
This research investigates the relationship between blood vessels and brain development in young children, particularly those with congenital heart disease. It focuses on understanding how these interactions may lead to brain injuries, especially in the white matter of the brain. The research employs advanced techniques such as single molecule fluorescent in situ hybridization and confocal microscopy to analyze brain injury specimens. By studying the effects of hypoxic injury on specific brain cells, the research aims to uncover critical insights into brain maturation and injury recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have congenital heart disease and may be experiencing related brain injuries.
Not a fit: Patients without congenital heart disease or those outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for brain injuries in children with congenital heart disease.
How similar studies have performed: Previous research has shown promising results in understanding brain injuries related to congenital heart conditions, indicating that this approach has potential for success.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Chavali, Manideep — Oregon Health & Science University
- Study coordinator: Chavali, Manideep
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.