How blood vessel function affects brain fluid clearance in Lewy body dementia
Interaction between microvascular function and CSF clearance in Lewy body dementia
This study is looking at how blood flow in the brain affects the removal of waste, like harmful proteins, in people with Lewy body dementia, using advanced MRI technology to help us understand how these factors relate to memory and thinking problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hugo W. Moser Res Inst Kennedy Krieger NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10661984 on NIH RePORTER |
What this research studies
This research investigates the relationship between blood vessel function and the clearance of cerebrospinal fluid (CSF) in patients with Lewy body dementia. It aims to understand how changes in blood flow may impact the brain's ability to remove waste, which is crucial for maintaining cognitive health. The study employs advanced non-invasive MRI techniques to assess both microvascular and lymphatic functions in the brain, providing insights into their interactions and effects on dementia pathology. By capturing in vivo data, the research seeks to clarify the mechanisms linking these systems to cognitive impairment and the presence of harmful proteins like beta-amyloid and tau.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Lewy body dementia who are experiencing cognitive decline.
Not a fit: Patients with other types of dementia or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving brain health and cognitive function in patients with Lewy body dementia.
How similar studies have performed: While the interaction between microvascular function and CSF clearance is a relatively novel area of investigation, preliminary studies have shown promising results using similar imaging techniques.
Where this research is happening
Baltimore, United States
- Hugo W. Moser Res Inst Kennedy Krieger — Baltimore, United States (Active)
Researchers
- Principal investigator: Hua, Jun — Hugo W. Moser Res Inst Kennedy Krieger
- Study coordinator: Hua, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.