How blood vessel changes affect heart repair after a heart attack
Endothelial plasticity in cardiac repair after myocardial infarction
This study is looking at how blood vessels work after a heart attack to see how new ones form and how they can sometimes grow in a way that makes recovery harder, with the goal of finding better treatments to help your heart heal.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10900730 on NIH RePORTER |
What this research studies
This research investigates how blood vessels behave after a heart attack, focusing on the process of forming new blood vessels, known as neovascularization. It uses advanced techniques like endothelial lineage tracing and single-cell RNA sequencing to understand how endothelial cells change and contribute to heart repair. The study aims to identify the mechanisms that lead to abnormal blood vessel formation, which can hinder recovery, and explores potential treatments to improve heart function post-heart attack.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a myocardial infarction and are seeking innovative treatment options to aid their recovery.
Not a fit: Patients who have not had a heart attack or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance heart repair and improve recovery outcomes for patients who have suffered a heart attack.
How similar studies have performed: Previous research has shown promising results in understanding endothelial cell behavior in heart repair, indicating that this approach has potential for success.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Fan, Yi — University of Pennsylvania
- Study coordinator: Fan, Yi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.