How blood vessel cells influence metabolism and energy balance
Metabolic crosstalk through vascular endothelium-secreted factors
This study is looking at how cells that line our blood vessels help manage our body's energy and metabolism, especially when food is scarce, and it’s exploring a specific protein that might improve insulin sensitivity and fat function, which could lead to new ways to help people with obesity and insulin resistance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11060896 on NIH RePORTER |
What this research studies
This research investigates the role of endothelial cells, which line blood vessels, in regulating metabolism and energy balance in the body. It focuses on how these cells communicate with organs to provide essential nutrients during times of limited food availability. By studying the effects of a specific protein, BMPER, on insulin sensitivity and fat tissue function, the research aims to uncover mechanisms that could help manage metabolic disorders like obesity and insulin resistance. Patients may benefit from insights that could lead to new treatments targeting these metabolic pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing metabolic disorders, particularly those with obesity or insulin resistance.
Not a fit: Patients who do not have metabolic disorders or related conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating metabolic disorders such as obesity and insulin resistance.
How similar studies have performed: Previous research has shown promising results in understanding the role of endothelial cells in metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Pi, Xinchun — Baylor College of Medicine
- Study coordinator: Pi, Xinchun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.