How blood vessel cells contribute to blood clot formation
Regulation of endothelial cell phosphatidylserine in thrombosis
This study is looking at how certain cells in your blood vessels help form clots, which can lead to heart attacks and strokes, and it’s exploring a special substance that could help us find new ways to prevent dangerous clots from forming.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11001473 on NIH RePORTER |
What this research studies
This research investigates the role of endothelial cells in the formation of blood clots, which are critical in cardiovascular diseases like heart attacks and strokes. It focuses on a specific phospholipid, phosphatidylserine (PS), which is essential for activating blood coagulation enzymes. The study aims to understand how PS is externalized from the cell membrane and how this process can be targeted to reduce thrombosis. By examining the mechanisms involved, the research seeks to identify new strategies for preventing harmful blood clots.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for cardiovascular diseases, such as those with a history of heart attacks, strokes, or venous thromboembolism.
Not a fit: Patients who do not have cardiovascular disease or related risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent dangerous blood clots, improving outcomes for patients with cardiovascular diseases.
How similar studies have performed: Previous research has shown that targeting phosphatidylserine exposure can reduce thrombosis in animal models, indicating potential success for similar approaches in this study.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Schmaier, Alec Andrew — Beth Israel Deaconess Medical Center
- Study coordinator: Schmaier, Alec Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.