How blood vessel cells affect calcium buildup in arteries
Endothelial Regulation of Vascular Calcification
This study is looking at how certain cells that line our blood vessels might contribute to the hardening of those vessels, which can make heart problems worse, and it hopes to find ways to help prevent or treat this condition for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10997359 on NIH RePORTER |
What this research studies
This research investigates the role of endothelial cells, which line blood vessels, in the process of vascular calcification, a condition that complicates cardiovascular diseases. The study focuses on understanding how different types of endothelial cells contribute to this calcification and whether they can be targeted to improve patient outcomes. By examining specific markers and genetic profiles of these cells in a mouse model, researchers aim to uncover mechanisms that could lead to new therapeutic strategies. Patients may benefit from insights gained about preventing or treating vascular calcification, which can lead to serious health complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular disease who are at risk for vascular calcification.
Not a fit: Patients without cardiovascular disease or those not experiencing vascular calcification may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce vascular calcification, improving cardiovascular health.
How similar studies have performed: Previous research has shown promising results in understanding the role of endothelial cells in vascular conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Bostrom, Kristina I — University of California Los Angeles
- Study coordinator: Bostrom, Kristina I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.