How blood flow direction affects the behavior of blood vessel cells
Official title: Contribution of Endothelial Planar Cell Polarity pathways in Blood Flow Direction Sensing
Funded at Yale University · NIH-10988248 · Data updated 2026-11-12
This study is looking at how the cells that line our blood vessels react to the direction of blood flow, which could help us understand how to prevent heart problems like atherosclerosis.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31HL168920-02 |
| Project ID | NIH-10988248 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for atherosclerosis or those with existing cardiovascular conditions.
✕Less likely to help
Patients with conditions unrelated to vascular health or those not at risk for atherosclerosis may not benefit from this research.
What this research studies
This research investigates how vascular endothelial cells (VECs), which line blood vessels, respond to the direction of blood flow. It focuses on understanding the mechanisms by which these cells sense flow direction and how this affects their alignment and inflammatory responses. The study aims to uncover the role of specific proteins involved in this process, which could lead to insights into preventing conditions like atherosclerosis. By examining the interactions between these proteins and blood flow, the research seeks to provide a deeper understanding of vascular health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating atherosclerosis and other vascular diseases.
How similar studies have gone: Previous research has shown that understanding endothelial cell behavior in response to blood flow can lead to significant advancements in cardiovascular health, indicating that this approach has potential for success.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: X, Shaka — Yale University
- Study coordinator: X, Shaka
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.