How blood flow affects the removal of dead cells in blood vessel lining
Impact of hemodynamics on efferocytosis in endothelial cells
['FUNDING_R01'] · GEORGIA STATE UNIVERSITY · NIH-10791790
This study looks at how different blood flow patterns affect the ability of cells lining your blood vessels to remove dead cells, which is important for keeping your blood vessels healthy and preventing heart problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGIA STATE UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10791790 on ClinicalTrials.gov |
What this research studies
This research investigates how different types of blood flow impact the ability of endothelial cells, which line blood vessels, to clear away dead cells. It focuses on understanding how shear stress, caused by blood flow, influences a process called efferocytosis, which is crucial for maintaining healthy blood vessels and preventing atherosclerosis. By examining the effects of various flow conditions, the study aims to uncover mechanisms that could lead to improved treatments for cardiovascular diseases. Patients may benefit from insights gained about how to enhance endothelial function and reduce the risk of atherosclerosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for atherosclerosis or those with existing cardiovascular conditions.
Not a fit: Patients with conditions unrelated to cardiovascular health or those who do not have issues with endothelial function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating atherosclerosis, potentially improving cardiovascular health for many patients.
How similar studies have performed: Previous research has shown that understanding shear stress and its effects on endothelial cells can lead to significant advancements in cardiovascular treatment, indicating that this approach has potential for success.
Where this research is happening
ATLANTA, UNITED STATES
- GEORGIA STATE UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DING, ZUFENG — GEORGIA STATE UNIVERSITY
- Study coordinator: DING, ZUFENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.