How blood flow affects the health of blood vessel cells
Metabolism and cell cycle as mediators of fluid shear stress effects on vascular endothelium in health and disease
This study is looking at how different blood flow patterns affect the cells in our blood vessels, especially in relation to atherosclerosis, which can cause heart problems, to find out how we might better protect against or treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11167741 on NIH RePORTER |
What this research studies
This research investigates how different types of blood flow impact the cells lining blood vessels, particularly in relation to atherosclerosis, a condition that can lead to heart disease. It focuses on the effects of normal versus disturbed blood flow on cell metabolism and inflammation. The study will utilize both laboratory experiments and animal models to explore these mechanisms, aiming to understand how certain cellular processes can either protect against or promote disease. By examining specific pathways involved in these processes, the research seeks to uncover potential targets for new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for atherosclerosis, particularly those with metabolic or inflammatory conditions.
Not a fit: Patients with established atherosclerosis or those who do not have risk factors for cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating atherosclerosis and related cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of blood flow dynamics in vascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Schwartz, Martin a — Yale University
- Study coordinator: Schwartz, Martin a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.