How blood flow affects the cells lining blood vessels
Homeostatic regulation of endothelial mechanotransduction
['FUNDING_OTHER'] · OKLAHOMA MEDICAL RESEARCH FOUNDATION · NIH-11018565
This study looks at how the cells lining your blood vessels react to changes in blood flow, which could help us understand and prevent problems with blood vessel health that affect patients like you.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OKLAHOMA MEDICAL RESEARCH FOUNDATION (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-11018565 on ClinicalTrials.gov |
What this research studies
This research investigates how the cells that line blood vessels, known as endothelial cells, respond to changes in blood flow. It focuses on the mechanisms by which these cells detect and adapt to the forces exerted by blood, particularly through specific proteins that regulate inflammation and vessel structure. By examining how these responses can go awry, the study aims to uncover potential pathways that lead to vascular disorders. Patients may benefit from insights into how to better manage or prevent conditions related to blood vessel dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with known vascular disorders or those at risk for cardiovascular diseases.
Not a fit: Patients with non-vascular related conditions or those not experiencing any cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating vascular disorders and improving cardiovascular health.
How similar studies have performed: Other research has shown promising results in understanding the role of mechanotransduction in vascular health, indicating that this approach has potential for success.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- OKLAHOMA MEDICAL RESEARCH FOUNDATION — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COON, BRIAN GENE — OKLAHOMA MEDICAL RESEARCH FOUNDATION
- Study coordinator: COON, BRIAN GENE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: blood vessel disorder