How blood flow affects cancer cells in the bloodstream
Influence of hemodynamic shear stress on circulating tumor cells
This study is looking at how cancer cells that travel in the bloodstream manage to survive tough conditions, which could help us find better treatments to target these cells and stop cancer from spreading.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11037902 on NIH RePORTER |
What this research studies
This research investigates how circulating tumor cells (CTCs), which are cancer cells found in the bloodstream, survive various challenges, including the forces exerted by blood flow. The study aims to understand the mechanisms that allow these cells to resist destruction by these forces, which could help explain their role in cancer spread (metastasis). By examining how CTCs adapt to these mechanical stresses, the research seeks to identify potential new therapies that could enhance the destruction of these cells in circulation. Patients may benefit from insights that could lead to improved cancer treatments targeting CTCs.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients with circulating tumor cells in their bloodstream.
Not a fit: Patients without circulating tumor cells or those with non-metastatic cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce the survival of circulating tumor cells, potentially decreasing cancer metastasis.
How similar studies have performed: Other research has shown promise in understanding the mechanics of circulating tumor cells, suggesting that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Henry, Michael D — University of Iowa
- Study coordinator: Henry, Michael D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.