How blood flow affects a protein important for lung health
Official title: The Impact of Shear Stress on Aquaporin 1 Expression in the Pulmonary Endothelium
Funded at Johns Hopkins University · NIH-10998236 · Data updated 2026-11-12
This study is looking at how changes in blood flow affect a protein important for lung function, which could help us find new treatments for lung problems like pulmonary embolism and pulmonary hypertension.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $83,932 |
| NIH project number | 1F32HL176197-01 |
| Project ID | NIH-10998236 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from pulmonary conditions such as pulmonary hypertension or those at risk of pulmonary embolism.
✕Less likely to help
Patients with stable pulmonary conditions that do not involve shear stress alterations may not benefit from this research.
What this research studies
This research investigates how changes in blood flow, specifically shear stress, influence the expression of Aquaporin 1 (AQP1) in the cells lining the lungs. By studying pulmonary endothelial cells under different flow conditions, the researchers aim to understand the biochemical changes that occur when shear stress is altered, which can happen in conditions like pulmonary embolism and pulmonary hypertension. The study utilizes in vitro models to replicate these conditions and assess the impact of shear stress on AQP1 expression, which is crucial for maintaining lung function. The findings could lead to new therapeutic strategies for lung diseases associated with abnormal blood flow.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung function in patients with pulmonary diseases.
How similar studies have gone: Previous research has shown that understanding shear stress effects on endothelial cells can lead to significant advancements in treating vascular-related diseases.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Croglio, Michael — Johns Hopkins University
- Study coordinator: Croglio, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.