How blood donor sex and testosterone levels affect blood transfusion outcomes
Effect of blood donor sex and inter-individual variability in plasma testosterone on the transfusion effectiveness and hemostatic potential of red blood cells and platelets
This study is looking at how the sex of blood donors and their testosterone levels might affect how well and safely blood transfusions work, so we can find ways to improve outcomes for patients receiving blood.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vitalant NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-10930183 on NIH RePORTER |
What this research studies
This research investigates how the sex of blood donors and their testosterone levels influence the effectiveness and safety of blood transfusions. The study aims to understand the cellular changes in red blood cells and platelets that occur due to variations in testosterone, whether from natural differences or therapeutic interventions like testosterone replacement therapy. By analyzing blood components from different donors, the research seeks to identify factors that may lead to better transfusion outcomes for patients. The methodology includes comparing blood samples from donors with varying testosterone levels and assessing their performance in transfusion settings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals requiring blood transfusions, particularly those with conditions affecting blood cell function.
Not a fit: Patients who do not require blood transfusions or have stable conditions that do not necessitate such interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved blood transfusion practices, enhancing patient recovery and safety.
How similar studies have performed: Previous research has indicated that variations in donor characteristics can impact transfusion outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
Scottsdale, United States
- Vitalant — Scottsdale, United States (Active)
Researchers
- Principal investigator: Kanias, Tamir — Vitalant
- Study coordinator: Kanias, Tamir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.